Research Overview

Synthetic biology has the potential to provide solutions for the challenges of modern society and pave new ways to understand life. Our ability to design biological systems by synthetic biology is dependent on our ability to regulate gene expression. At Jang Laboratory, we integrate rational design and artificial evolution to create novel gene regulation systems for understanding fundamental biological processes and engineering valuable phenotypes. Particularly, we focus on nucleic acids that offer new opportunities for developing artificial gene regulators based on their programmability, versatility, low genetic footprint, and economic production both in vivo and in vitro.​ Using artificial gene regulators, we engineer microorganisms for improving energy, environment, and human health.

​

Keywords: synthetic genetic circuit; rational design; artificial evolution; aptamer; SELEX;

Applications: biosensor; microbiome engineering; metabolic engineering; molecular diagnosis