Synthetic biology has the potential to provide solutions for the challenges of modern society and pave new ways to understand life. Our ability to design biological systems by synthetic biology is dependent on our ability to regulate gene expression. At Jang Laboratory, we integrate rational design and artificial evolution to create novel gene regulation systems for understanding fundamental biological processes and engineering valuable phenotypes. Particularly, we focus on nucleic acids that offer new opportunities for developing artificial gene regulators based on their programmability, versatility, low genetic footprint, and economic production both in vivo and in vitro. Using artificial gene regulators, we engineer microorganisms for improving energy, environment, and human health.
Keywords: synthetic genetic circuit; rational design; artificial evolution; aptamer; SELEX;
Applications: biosensor; microbiome engineering; metabolic engineering; molecular diagnosis
Our group aims at (re)designing biological systems through rational engineering of genetic circuits mainly using nucleic acid-based gene regulators.
Dynamic gene regulators
Complex genetic circuits
Our group is interested in developing synthetic biology tools for studying and accelerating the evolution of biomolecules and cells.
In vitro evolution (SELEX)
In vivo evolution
Our group is focusing on integrating Synthetic Biology and Artificial Evolution for applications in